Protein key to elevated stroke and heart risk say researchers

Scientists have said that a “Pac Man” cell which digests fat in the blood would dramatically reduce the chances of stroke and heart attacks if a key protein was removed from its make up.

The team from the University of Connecticut (UConn) has studied the way in which macrophages travel through the body and the role they play, concluding that it can do more harm than good

“Macrophages travel through our arteries, gobbling fat the way Pac-man gobbled ghosts,” the study said. “But fat-filled macrophages can narrow blood vessels and cause heart disease.” The team said deleting a protein could prevent this and potentially prevent heart attacks and strokes in humans.

Macrophages are large white blood cells that cruise through our body as a kind of clean-up crew, clearing hazardous debris. But in people with atherosclerosis—fatty deposits and inflammation in their blood vessels— macrophages can create new threats. They eat excess fat inside artery walls, but that fat causes them to become foamy. And foamy macrophages tend to encourage inflammation in the arteries and sometimes bust apart plaques, freeing clots that can cause heart attack, stroke or embolisms elsewhere in the body.

Changing how macrophages express a certain protein could prevent that kind of bad behaviour, according to the researchers at UConn Health. They found that the protein, called TRPM2, is activated by inflammation. It signals macrophages to start eating fat. Since inflammation of the blood vessels is one of the primary causes of atherosclerosis, TRPM2 gets activated regularly. Such activation pushes macrophage activity, which leads to more foamy macrophages and potentially more inflamed arteries.

The way that TRPM2 activated macrophage activity was surprising, says Lixia Yue, a UConn School of Medicine cell biologist.

“They form a vicious cycle promoting the development of atherosclerosis,” Yue added.

Yue and Pengyu Zong, a graduate student and the first author of the paper, demonstrated one way to stop the cycle, at least in mice. They deleted TRPM2 from a type of lab mouse that tends to get atherosclerosis. Deleting that protein didn’t seem to hurt the mice, and it prevented the macrophages from getting foamy. It also alleviated the animals’ atherosclerosis.

Now Yue and Pengyu Zong, and the rest of the team are looking at whether increased TRPM2 expression in monocytes (precursors of macrophages) in the blood correlates with severity of cardiovascular disease in humans. If they find that there is a correlation, high levels of TRPM2 might be a risk marker for heart attack and stroke.

Follow us on twitter: @risksEmerging

Ethical Hacking does not require coding, but it is difficult to be an effective hacker without it.

👉 Follow #SKILLOGIC for more updates!

🔗Visit: https://skillogic.com/ethical-hacking-certification-course/

#hacking #cybersecurity #ethicalhacking #hacker #hackers #ethicalhacker #technology #hack #Coding

🗣#Hackers are always prying on our #personaldata.

At #Hypersign, our omnichain #decentralized platform is built to safeguard your digital privacy.

More👇
http://hypersign.id

#dataprivacy #databreach $HID

Exciting to see our partner @ODPC_KE represented by Ms. Immaculate Kassait, MBS, the Data Commissioner speak at the 15th Computer, Privacy and Data Protection (CPDP) Conference in Brussels with support from @giz_gmbh. #dataprivacy #dataprotection in transitional times!

3

Why banking infrastructure is broken blog #4 – how will the fabric of money change? https://buff.ly/3MEcJER #FinTech #Payments #Technology

New #DeepLearning technique paves path to pizza-making #robots
http://ow.ly/HnMk50JfG66

#AIEthics #MachineLearning #AI #Python #DeepLearning #IoT #100DaysOfCode #fintech #insurtech #nocode #bitcoin #cybersecurity #cybersecurite #metaverse

Sourcepass Names New Chief Information Security Officer #infosec #infosecurity #cybersecurity #threatintel #threatintelligence #hacking #cybernews #cyberattack #threathunting
#cloudsecurity #cloudcomputing #malware #ransomware #devops #dfir http://cyberiqs.com/latestnews

Perspective: Ray Liotta delivered one of cinema’s greatest breakout performances https://wapo.st/3MTO4fC

🇨🇦

I just published a new post on my @buymeacoffee!

Back in Ottawa
https://www.buymeacoffee.com/AlexVerbeek/back-ottawa

Load More...
SHARE: