Global coronavirus vaccines strategy created as concern over future pandemics remains

Leading research organisations from across the world have launched a global strategy to coordinate the complex research activities necessary for the development of new, and broader coronavirus vaccines.

The aim is to develop more effective, longer lasting vaccines against continually emerging SARS-CoV-2 variants, and against new coronaviruses that may emerge in the future, after one leading scientist said the world had been taught a “hard lesson” by the Covid-19 pandemic.

The Coronavirus Vaccines Research and Development Roadmap (CVR) is led by the US Center for Infectious Disease Research and Policy (CIDRAP) at the University of Minnesota. It is the product of an international collaboration of 50 scientific experts from around the world, who have combined to create a unified strategy to make these “critically needed” vaccines a reality.

“The response of the scientific and medical communities to the development and delivery of COVID-19 vaccines has been incredible, but as new variants emerge and immunity begins to wane we need newer technologies. It’s vital that we continue to develop vaccine candidates to help keep us safe from the next virus threats,” said professor Jonathan Heeney, head of the Lab of Viral Zoonotics at the University of Cambridge and advisor on the international CVR Taskforce.

Heeney, who is also a Fellow at Darwin College, Cambridge, is leading an ongoing clinical trial to evaluate an innovative coronavirus vaccine he developed at the University of Cambridge and spin-out company DIOSynVax. Administered needle-free using a blast of air, the vaccine primes the immune system to give a broader protective response to coronaviruses and is a step towards developing a future-proofed coronavirus vaccine.

Last year DIOSynVax was awarded $42 million from the Coalition for Epidemic Preparedness Innovations (CEPI) and the UK Government to support this work.

“The COVID-19 pandemic marks the third time in just twenty years that a coronavirus has emerged to cause a public health crisis,” said Michael T. Osterholm, director, University of Minnesota regents professor and McKnight presidential endowed chair in Public Health.

He added: “The COVID-19 pandemic taught us the hard lesson that we must be better prepared. Rather than waiting for a fourth coronavirus to emerge — or for the arrival of an especially dangerous SARS-CoV-2 variant — we must act now to develop better, longer lasting and more broadly protective vaccines. If we wait for the next event to happen before we act, we will be too late.”

The emergence of SARS-CoV-2 in 2019 was preceded by an epidemic in 2003 caused by a different coronavirus called SARS-CoV. Then, in 2012, the Middle East respiratory syndrome coronavirus, or MERS-CoV, emerged. Coronaviruses can carry a high risk of death: for MERS-CoV, about one third of infections result in death, and approximately one in ten for SARS-CoV, although neither spreads easily from person to person.

In contrast, SARS-CoV-2, the virus that caused the COVID-19 pandemic, has a much lower fatality rate, but because it is so highly infectious between people, it had caused worldwide more than 650 million confirmed cases and 6.6 million deaths by the end of 2022. The team said even more concerning is the threat of a new coronavirus in the future that could be both highly transmissible and highly lethal. In addition, the emergence of new SARS-CoV-2 variants may further jeopardise the significant protection provided by current vaccines against severe disease and death.

“The CVR confronts these extraordinary threats with a detailed, comprehensive and coordinated plan to accelerate the development of long-lasting, broadly protective coronavirus vaccines capable of preventing severe disease and death, and potentially protect against infection and transmission,” It added. “The CVR further emphasises the goal that future broadly protective vaccines must be suitable for all regions worldwide, including remote areas and low- and middle-income countries.”

The report highlights different paths to success. One approach could involve a stepwise process, starting with vaccines to protect against variants of SARS-CoV-2. Another approach could focus on vaccines capable of protecting against multiple types of coronaviruses, including those likely to spill over from animals to humans in the future.

“The vaccines that we currently have for COVID-19 are the most important tool that we have in our battle against the pandemic,” said Charlie Weller, head of prevention, Infectious Diseases, at the Wellcome Trust. “But we can do better – by developing vaccines that give us broader protection – protection against new variants, protection from coronaviruses that have not yet emerged but might cause the next pandemic. We can discover new ways to deliver vaccines, such as skin patches or intranasal vaccines – and maybe even vaccines that could block transmission. This roadmap creates the structured plan that will give us the tools we need to better protect ourselves, our families and our communities around the world.”